354 Charlton Avenue is a 2 1/2 story, 3 bay, rectangular plan, Shingle Style, wood frame, residential building. Built c. 1899, the stucco and wood shingle-clad house features a crossed gambrel roof with a Palladian window in the front-facing gambrel apex. The wrap-around porch is supported by triple Doric column clusters, and trimmed with a wooden entablature. The main cornice line is ornamented with dentils. Benjamin T. Kissam was the first owner of the house. In the 1920s, the house was owned by William L. Schultz, a Hoboken-based soap manufacturer.