380 Charlton Avenue is a 2 1/2 story, 3 bay, rectangular plan, Colonial Revival, wood frame, residential building. Built c. 1920, the wood shingle-clad house has a hipped roof with matching dormers, paired bracket-supported overhanging eaves, cantilevered bays, multi-pane upper sash, sidelit entrance, and a paired, column-supported portico. The main block of the house is flanked by a one story side porch and a matching porte-cochere.