425 Vose Avenue is a 2 1/2 story, 3 bay, rectangular plan, Shingle style, wood frame, residential building. Constructed in 1880, the brick and wood shingle-clad house features a slate-clad, crossed gable roof with multiple level eaves, cornice returns, and decorative vergeboards. Other architectural details include a fluted pier-supported, pedimented entrance porch and porte-cochere, massive brick chimneys and decorative window groupings with stained glass windows and transoms. The first floor is finished with brick, the upper stories are clad with patterned shingles. The house was originally owned by Augusta E. Matthews and her husband Watson Matthews, a Village Trustee in the late 19th century. Due to its proximity to the Mountain Station, it was one of the first homes in the Village to have telephone service.